Homayoun Ahmadpanahi, the project manager, said the aim of the research was to synthesize and introduce a new nanocarrier for a more effective and targeted drug delivery for treating stomach ulcers.
“Treatment costs reduction, a boost in the effectiveness of the drug and a decrease in drug consumption side effects are the benefits of using this nanocarrier as the drug delivery system,” he said.
He further added that the synthesized nanocarrier in this project is comprised of a polymer component and an oxide component, adding “the magnetic nanoparticles of iron have been modified by smart polymers; this allows the drug delivery to be done locally and under controlled conditions, and at the same time, using the temperature-sensitive sorbents minimizes the drug’s side effects.”
According to him, the magnetic iron oxide nanoparticles have been synthesized through co-precipitation method and by using iron complexes, and their surfaces have been modified by organic compounds and smart polymers. The nanocarriers were then used as targeted drug delivery for Famotidine, commonly used in the treatment of peptic ulcer disease.
The results of the research indicate that almost 73 per cent of the drug loaded into the nanocarrier has been released in the simulated gastric fluid environment within one hour.
The results of the research have been published in International Journal of Pharmaceutics, vol. 476, 2014, pp. 70-76.
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